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Peptide Knowledge Hub

Peptide Therapy Education Center

Explore our complete reference guide to 36+ signaling peptides used in modern longevity, recovery, metabolic, and performance medicine. Use it to learn — then review your goals with Signal Wellness.

9 new peptides just added
Showing 36 peptides
Metabolic & GLP-1 Weight Loss

Semaglutide

A GLP-1 receptor agonist that mimics the gut hormone glucagon-like peptide-1. It slows gastric emptying, signals fullness to the brain, and improves insulin sensitivity for sustained weight loss.

Key Signals:
Eliminates compulsive food cravings & 'food noise'
Regulates blood sugar & insulin response
Supports steady, sustained weight loss
Typical use: Once-weekly as part of a guided metabolic protocol.
Metabolic & GLP-1 Weight Loss

Tirzepatide

A first-in-class dual GLP-1 and GIP receptor agonist. By activating two incretin pathways it delivers greater appetite suppression and fat loss than single-pathway agents.

Key Signals:
Superior weight-loss results vs. GLP-1 alone
Improved insulin sensitivity & glycemic control
Powerful, long-lasting appetite regulation
Typical use: Once-weekly with titrated dosing.
Metabolic & GLP-1 Weight Loss
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Retatrutide

A next-generation triple agonist of GLP-1, GIP, and glucagon receptors. The added glucagon signaling increases energy expenditure and hepatic fat mobilization.

Key Signals:
Enhanced fat loss & metabolic flexibility
Increased resting energy expenditure
Improved lipid & glucose metabolism
Typical use: Once-weekly; an emerging option for advanced metabolic goals.
Metabolic & GLP-1 Weight Loss
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Cagrilintide

A long-acting amylin analogue that promotes deep satiety. Often combined with semaglutide (CagriSema) for synergistic appetite control and weight loss.

Key Signals:
Powerful, prolonged fullness & satiety
Reduced caloric intake without deprivation
Synergistic weight loss when stacked with GLP-1
Typical use: Once-weekly, frequently paired with a GLP-1 agonist.
Metabolic & GLP-1 Weight Loss

MOTS-C

A mitochondrial-derived peptide that improves insulin sensitivity and metabolic homeostasis by regulating energy production at the cellular level.

Key Signals:
Improved insulin sensitivity & glucose uptake
Enhanced exercise capacity & metabolic function
Supports weight management & energy balance
Typical use: Often cycled with training or metabolic protocols.
Metabolic & GLP-1 Weight Loss

5-Amino-1MQ

A small molecule that inhibits NNMT, an enzyme linked to fat accumulation. This raises intracellular NAD+ and shifts cells toward fat oxidation.

Key Signals:
Promotes targeted fat loss
Boosts cellular NAD+ & energy
Supports metabolic & weight-loss goals
Typical use: Oral capsule taken daily as part of a metabolic optimization plan.
Metabolic & GLP-1 Weight Loss

AOD-9604

A modified fragment of human growth hormone (amino acids 177–191) that stimulates lipolysis (fat breakdown) and inhibits lipogenesis — without affecting blood sugar or growth.

Key Signals:
Targets stubborn fat stores
Supports weight loss & fat metabolism
May aid cartilage & joint repair
Typical use: Often used in fat-loss and recovery cycles.
Metabolic & GLP-1 Weight Loss

Lipo-B (MIC+B12)

A lipotropic blend combining Methionine, Inositol, Choline (MIC) and B-vitamins to help the liver metabolize fat and convert it into usable energy.

Key Signals:
Accelerates fat metabolism & liver support
Natural energy boost from B12
Complements GLP-1 & weight-loss protocols
Typical use: 1–2 times weekly as part of a weight-loss protocol.
Cellular Energy & Longevity
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SANA (MVD1)

An emerging mitochondrial-support peptide designed to optimize energy production, reduce oxidative stress, and promote cellular repair at the mitochondrial level.

Key Signals:
Mitochondrial function & cellular energy
Reduced oxidative stress
Supports longevity & cellular resilience
Typical use: Used in guided longevity cycles.
Cellular Energy & Longevity

Glutathione

The body's master antioxidant, composed of three amino acids. It neutralizes free radicals, supports detoxification, and recycles other antioxidants.

Key Signals:
Powerful detoxification & liver support
Immune system reinforcement
Skin brightening & oxidative-stress defense
Typical use: Available as a nasal spray, oral, or in guided antioxidant protocols.
Cellular Energy & Longevity

NAD+

A vital coenzyme found in every cell that powers mitochondrial energy production and activates sirtuins — proteins that govern DNA repair and aging.

Key Signals:
Restores cellular ATP energy & fights fatigue
Activates DNA repair & longevity pathways
Supports brain function & metabolism
Typical use: Oral lozenge or as part of anti-aging protocols; delivery personalized to you.
Cellular Energy & Longevity
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SS-31 (Elamipretide)

A mitochondria-targeted peptide that binds cardiolipin in the inner mitochondrial membrane, restoring energy production and reducing cellular stress.

Key Signals:
Optimizes mitochondrial energy output
Cardiac, renal & cellular support
Reduces oxidative damage
Typical use: Used in specialized longevity protocols.
Cellular Energy & Longevity
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FOXO4-DRI

A senolytic peptide that disrupts the interaction between FOXO4 and p53, selectively forcing senescent ('zombie') cells to self-clear so healthy tissue can regenerate.

Key Signals:
Clears senescent cells
Promotes tissue rejuvenation
Supports healthy aging & longevity
Typical use: Used in pulsed senolytic cycles.
Tissue Repair & Healing

BPC-157 & TB-500

A synergistic blend: BPC-157 (a gastric-derived peptide) accelerates angiogenesis and gut healing, while TB-500 (Thymosin Beta-4) promotes cell migration and tissue remodeling.

Key Signals:
Accelerated tendon, ligament & joint repair
Gut healing & leaky-gut support
Reduced systemic inflammation & faster recovery
Typical use: Targeted or systemic; oral BPC available for gut support.
Tissue Repair & Healing

ARA-290

A synthetic 11-amino-acid peptide derived from erythropoietin that reduces inflammation and supports nerve repair — without stimulating red blood cell production.

Key Signals:
Relief from neuropathy & nerve pain
Powerful anti-inflammatory action
Supports tissue & nerve repair
Typical use: Used in pain and neuropathy protocols.
Tissue Repair & Healing

Cartalax

A peptide bioregulator designed to target cartilage tissue, supporting the repair and maintenance of joint cartilage and connective structures.

Key Signals:
Joint health & cartilage regeneration
Improved mobility & flexibility
Supports connective-tissue repair
Typical use: Oral capsule; used in joint-health cycles.
Tissue Repair & Healing

GHK-Cu (Copper Peptide)

A naturally occurring copper-binding peptide that stimulates collagen and elastin production, promotes tissue remodeling, and supports skin and hair regeneration.

Key Signals:
Boosts skin collagen & elasticity
Supports hair growth & tissue repair
Anti-aging skin rejuvenation
Typical use: Topical serum, oral, or included in aesthetic blends.
Tissue Repair & Healing

KPV

A tripeptide derived from alpha-MSH with potent anti-inflammatory properties. It helps calm gut inflammation, skin conditions, and systemic inflammation.

Key Signals:
Reduces gut & systemic inflammation
Supports skin healing & conditions
Anti-inflammatory without immune suppression
Typical use: Oral or nasal spray.
Growth Hormone & Recovery

Sermorelin

A growth hormone-releasing hormone (GHRH) analog that stimulates your pituitary to produce its own natural growth hormone, preserving the body's natural feedback loop.

Key Signals:
Natural growth hormone release
Deeper, more restorative sleep
Improved body composition & recovery
Typical use: Taken at bedtime to mirror natural GH pulses.
Growth Hormone & Recovery

Tesamorelin

A stabilized GHRH analog (FDA-approved for HIV-associated lipodystrophy) that potently stimulates endogenous growth hormone, targeting visceral fat.

Key Signals:
Reduces stubborn visceral fat
Increases natural growth hormone
Improves body composition & lipids
Typical use: Often used in body-composition protocols.
Growth Hormone & Recovery

CJC-1295 + Ipamorelin

A synergistic blend: CJC-1295 (a GHRH analog) extends the GH pulse while Ipamorelin (a GHRP) amplifies it — without spiking cortisol, prolactin, or appetite.

Key Signals:
Optimized natural growth hormone pulses
Deeper slow-wave sleep & recovery
Enhanced muscle tone, collagen & fat loss
Typical use: Taken at bedtime.
Growth Hormone & Recovery

IGF-1 LR3

A long-acting analog of insulin-like growth factor 1 that mediates many of growth hormone's muscle-building and recovery effects, with an extended half-life.

Key Signals:
Accelerated muscle growth & repair
Enhanced recovery between workouts
Supports fat loss & lean mass
Typical use: Used in advanced recovery and performance cycles.
Immune Support

LL-37

A cathelicidin-family antimicrobial peptide that directly neutralizes bacteria, viruses, and fungi while modulating the immune response and promoting wound healing.

Key Signals:
Broad-spectrum antimicrobial defense
Immune modulation & wound healing
Supports chronic infection & inflammation
Typical use: Nasal spray in immune-support protocols.
Immune Support

Thymosin Alpha-1

A thymic peptide that enhances T-cell maturation and immune signaling, helping the body mount a balanced, effective immune response.

Key Signals:
Strengthens immune defense & resilience
Supports infection recovery
Balances autoimmune & inflammatory responses
Typical use: Used in immune-optimization protocols.
Cognitive & Nootropic

Semax

An ACTH-derived neuropeptide that increases brain-derived neurotrophic factor (BDNF) and supports dopamine and serotonin signaling for focus and mental stamina.

Key Signals:
Sharpens focus & mental clarity
Enhances memory & cognitive endurance
Boosts BDNF for brain plasticity
Typical use: Nasal spray, often used during cognitively demanding periods.
Cognitive & Nootropic

Selank

An anxiolytic neuropeptide related to Semax that calms the nervous system and balances neurotransmitters without sedation or dependency.

Key Signals:
Reduces anxiety & nervous tension
Maintains calm, focused attention
Supports immune balance
Typical use: Nasal spray for stress and cognitive support.
Cognitive & Nootropic
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Dihexa

An angiotensin-IV analog developed to potently stimulate synapse formation and neurogenesis — considered one of the strongest cognitive-enhancing peptides.

Key Signals:
Supports memory & learning
Promotes neurogenesis & synaptogenesis
Enhances cognitive performance
Typical use: Oral in cognitive-optimization protocols.
Sexual Health & Hormone

PT-141 (Bremelanotide)

A melanocortin receptor agonist that works through the nervous system (rather than blood flow) to enhance sexual arousal and desire in both men and women.

Key Signals:
Enhances sexual arousal & libido
Works for men & women
Alternative pathway for ED & desire
Typical use: As needed, or nasal spray.
Sexual Health & Hormone
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Kisspeptin

A neuropeptide that stimulates GnRH release, upstream of the body's reproductive hormone cascade — supporting healthy libido and hormonal signaling.

Key Signals:
Supports natural libido & desire
Optimizes reproductive hormone signaling
Balances sexual health pathways
Typical use: Used in sexual-health and hormone protocols.
Sexual Health & Hormone

Oxytocin

The 'bonding hormone' neuropeptide that promotes social connection, trust, intimacy, and sexual function while calming the stress response.

Key Signals:
Enhances intimacy & social bonding
Supports sexual function & satisfaction
Reduces stress & promotes calm
Typical use: Nasal spray; used around intimacy or stress support.
Sleep, Skin & Aesthetics

DSIP (Delta Sleep-Inducing Peptide)

A neuropeptide that promotes deep, restorative slow-wave sleep and helps regulate the body's stress response and circadian rhythm.

Key Signals:
Deeper, more restorative sleep
Stress recovery & hormonal balance
Supports natural sleep cycles
Typical use: Taken at bedtime in sleep-optimization protocols.
Sleep, Skin & Aesthetics

Epithalon (Epitalon)

A pineal-gland peptide bioregulator that activates telomerase to help maintain telomere length — a key marker of cellular aging and longevity.

Key Signals:
Supports telomere length & longevity
Immune & sleep regulation
Promotes healthy aging
Typical use: Used in pulsed anti-aging cycles.
Sleep, Skin & Aesthetics

Pinealon

A peptide bioregulator targeting the pineal gland to support melatonin production, sleep regulation, and cognitive longevity.

Key Signals:
Supports healthy sleep & melatonin
Cognitive & anti-aging support
Helps regulate circadian rhythm
Typical use: Oral capsule; used in sleep and longevity cycles.
Sleep, Skin & Aesthetics

VIP (Vasoactive Intestinal Peptide)

A widely acting neuropeptide that supports circadian rhythm, immune balance, vascular tone, and gut health — often depleted in chronic stress.

Key Signals:
Supports circadian rhythm & sleep
Immune & inflammatory balance
Vascular & gut support
Typical use: Nasal spray in specialized protocols.
Sleep, Skin & Aesthetics
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Glow Blend

A Signal Wellness signature aesthetic blend built around skin-rejuvenating peptides (including GHK-Cu) to stimulate collagen, elasticity, and a radiant complexion from within.

Key Signals:
Radiant, glowing skin
Boosts collagen & elasticity
Supports hair & anti-aging
Typical use: Used in aesthetic and skin-health cycles.
Sleep, Skin & Aesthetics
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Klow Blend

A Signal Wellness signature blend formulated to calm the nervous system and support restful sleep and recovery. Ask our team whether it fits your protocol.

Key Signals:
Promotes calm & relaxation
Supports restful sleep & recovery
Signature Signal Wellness formulation
Typical use: Details personalized during consultation.

Unsure Which Peptide Protocol Fits Your Signals?

Take our specialized assessment to receive a customized recommendation and review it directly with Signal Wellness during a free consultation.

Educational & Regulatory Notice

This directory is provided for informational and educational purposes only and does not constitute medical advice. Signal Wellness operates as an educational and lifestyle optimization platform — we are not a medical facility and we do not dispense or prescribe medications. We offer quality research-grade peptides with a Certificate of Analysis (COA); these products are for research and laboratory use only and are not for human use. Medical-grade peptides are available through our partners at independent, licensed medical providers who conduct separate clinical evaluations. Access to specific therapies is at the sole discretion of the treating physician.